- Title
- Resistin is a predictor of asthma risk and resistin:adiponectin ratio is a negative predictor of lung function in asthma
- Creator
- Ballantyne, D.; Scott, H.; MacDonald-Wicks, L.; Gibson, P. G.; Wood, L. G.
- Relation
- Clinical and Experimental Allergy Vol. 46, Issue 8, p. 1056-1065
- Publisher Link
- http://dx.doi.org/10.1111/cea.12742
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2016
- Description
- Background: Adipokines, such as resistin and adiponectin, modify inflammation and may contribute to increased asthma risk and severity in obese people. Objective: To examine plasma resistin and resistin:adiponectin ratio (i) in asthmatics compared to healthy controls, (ii) according to asthma severity, obesity and gender (iii) following weight loss in obese asthmatics. Methods: In a cross-sectional observational study of asthmatic adults (n = 96) and healthy controls (n = 46), plasma resistin and adiponectin were measured. In a separate intervention study, obese asthmatic adults (n = 27) completed a 10-week weight loss intervention and plasma resistin and adiponectin concentrations were analysed. Results: Plasma resistin and resistin:adiponectin ratio were higher in asthma compared to controls and were higher again in subjects with a severe vs. mild-to-moderate asthma pattern. Amongst asthmatic subjects, resistin was not modified by gender or obesity, while adiponectin was lower in males and obese subjects. As a result, resistin:adiponectin ratio was higher in obese males, non-obese males and obese females, compared to non-obese females. In a logistic regression model, plasma resistin concentration was a predictor of asthma risk. In a multiple linear regression model, plasma resistin:adiponectin ratio was a negative predictor of FEV₁ in asthma. Following weight loss, neither resistin, adiponectin nor resistin:adiponectin ratio was changed. However, the change (Δ) in %body fat was associated with Δ resistin:adiponectin ratio. Post-intervention Δ resistin was negatively correlated with both ΔFRC and ΔRV. Conclusion and clinical relevance: This study demonstrates that resistin and resistin:adiponectin ratio are higher in asthma and are higher again in subjects who have more severe disease. Resistin:adiponectin ratio is highest in obese male asthmatics. As resistin is a predictor of asthma risk and resistin:adiponectin is a predictor of FEV1 in asthma, these adipokines may be contributing to the obese asthma phenotype, thus providing a potential therapeutic target for obese asthma.
- Subject
- asthma; obesity; adiponectin; adipokines
- Identifier
- http://hdl.handle.net/1959.13/1329163
- Identifier
- uon:26077
- Identifier
- ISSN:0954-7894
- Language
- eng
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